The goal of research in the Vedantam lab is to investigate the mechanism(s) of gut colonization by the diarrheic disease pathogen Clostridium difficile. Research is focused on the molecular characterization of non-toxin virulence factors of C. difficile and is aimed at designing interventions to combat as well as prevent C. difficile infection (CDI).
B.S. University of Bangalore, India
Ph.D. University of Illinois, Chicago
Post-Doctoral Fellowship: Loyola Univ. Medical Center,
School of Animal and Comparative Biomedical Sciences
University of Arizona
1117 E. Lowell Street Rm 303
Tucson, Arizona 85721
The goal of our research is to investigate the mechanism(s) of gut colonization by the diarrheic disease pathogen Clostridium difficile. C. difficileis the etiologic agent of C. difficile infection (CDI), a leading cause of nosocomial disease world-wide. CDI causes a spectrum of disease manifestations that range from mild diarrhea to lethal pseudomembranous colitis. Over 400,000 cases of CDI occur annually in the USA, imposing a $3.2 billion excess burden on the healthcare system. Research in our laboratory is focused on the molecular characterization of non-toxin virulence factors of C. difficile, and is aimed at designing interventions to combat as well as prevent CDI. We are also involved in multiple surveillance studies in Tucson-area hospitals that quantitate the incidence of both nosocomial and community-acquired CDI, via direct bacterial culture of patient samples as well as recovery of spores from abiotic environments such as hospital surfaces.
MIC/VSC 421B Microbial Techniques Laboratory (Fall Semester)
MIC/VSC 595A Colloquium – Topics in Bacterial Pathogenesis (Spring Semester)
Dr. Michael Mallozzi Post-Doctoral Fellow
Bryan Roxas Senior Research Specialist
Michelle Cho Graduate Student
Andrew Clark Graduate Student
Rebecca McQuade Graduate Student
Farhan Anwar Undergraduate Researcher
Kevin Lewis Undergraduate Researcher
Keith Lammers Undergraduate Researcher
Chelsea Adamson Undergraduate Researcher
Monteiro MA, Ma Z, Bertolo L, Jiao Y, Arroyo L, Hodgins D, Mallozzi M, Vedantam G
, Sagermann M, Sundsmo J, Chow H. Carbohydrate-based Clostridium difficile vaccines.
Expert Rev Vaccines. 2013 Apr;12(4):421-31. doi: 10.1586/erv.13.9. Review. PubMed PMID: 23560922.
Bertolo L, Boncheff AG, Ma Z, Chen YH, Wakeford T, Friendship RM, Rosseau J, Weese JS, Chu M, Mallozzi M, Vedantam G
, Monteiro MA. Clostridium difficile carbohydrates: glucan in spores, PSII common antigen in cells, immunogenicity of PSII in swine and synthesis of a dual C. difficile-ETEC conjugate vaccine.
Carbohydr Res. 2012 Jun 1;354:79-86. doi: 10.1016/j.carres.2012.03.032. Epub 2012 Apr 2. PubMed PMID: 22533919.
Vedantam G, Viswanathan VK. A more perfect union. Gut Microbes. 2011 May-Jun;2(3):125-6. Epub 2011 May 1. PubMed PMID: 21637032.
Merrigan, M., Venugopal, A., Mallozzi, M., Roxas, B., Viswanathan, V.K., Johnson, S., Gerding, D.N., Vedantam, G.
. 2010. Human hypervirulent Clostridium difficile strains exhibit increased sporulation as well as robust toxin production.
J Bacteriol. 2010, 192(19):4904-11. PMCID: PMC2944552.
Lepp, D., Roxas, B., Parreira, V.R., Marri, P.R., Rosey, E.L., Gong, J., Songer, J.G., Vedantam, G
., and Prescott, J.F. Identification of Novel Pathogenicity Loci in Clostridium perfringens Strains That Cause Avian Necrotic Enteritis.
2010. PLoS ONE 5(5): e-PUB 05/24/2010., e10795. PMCID: PMC2879425.
Coursodon, C.F., Trinh, H.T., Mallozzi, M, Vedantam, G.
, Glock R.D., Songer J.G. 2010. Clostridium perfringens alpha toxin is produced in the intestines of broiler chicks inoculated with an alpha toxin mutant.
Anaerobe, 2010 Dec;16(6):614-7. PMID: 20934524
Nishiguchi, M.K., Hirsch, A.M., Devinney, R., Vedantam, G
., Riley, A.M., and Mansky, L.M. Deciphering evolutionary mechanisms between mutualistic and pathogenic symbioses. Viet et Milieu – Life and Environment
. 2008, 58 (2): 87-106. PMCID: PMC2719982